Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults.
Identifieur interne : 001002 ( Main/Exploration ); précédent : 001001; suivant : 001003Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults.
Auteurs : J. Coulson [Royaume-Uni] ; L. Bagley [Royaume-Uni] ; Y. Barnouin [Royaume-Uni] ; S. Bradburn [Royaume-Uni] ; G. Butler-Browne [France] ; H. Gapeyeva [Estonie] ; J-Y Hogrel [France] ; T. Maden-Wilkinson [Royaume-Uni] ; A B Maier [Pays-Bas] ; C. Meskers [Pays-Bas] ; C. Murgatroyd [Royaume-Uni] ; M. Narici [Royaume-Uni] ; M. P Suke [Estonie] ; L. Sassano [Royaume-Uni] ; S. Sipil [Finlande] ; N. Al-Shanti [Royaume-Uni] ; L. Stenroth [Finlande] ; D A Jones [Royaume-Uni] ; J S Mcphee [Royaume-Uni]Source :
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [ 1433-2965 ] ; 2017.
Abstract
Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young.
DOI: 10.1007/s00198-017-4104-2
PubMed: 28585053
Affiliations:
- Estonie, Finlande, France, Pays-Bas, Royaume-Uni
- Angleterre, Finlande-Centrale, Hollande-Septentrionale, Nottinghamshire, Île-de-France
- Amsterdam, Jyväskylä, Nottingham, Paris
- Université de Jyväskylä, Université de Nottingham
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Maden-Wilkinson</name><affiliation wicri:level="1"><nlm:affiliation>School of Physical Activity and Health, Sheffield Hallam University, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Physical Activity and Health, Sheffield Hallam University, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Maier, A B" sort="Maier, A B" uniqKey="Maier A" first="A B" last="Maier">A B Maier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Human Movement Sciences, MOVE Research Institute, Vrij University, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Movement Sciences, MOVE Research Institute, Vrij University, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Meskers, C" sort="Meskers, C" uniqKey="Meskers C" first="C" last="Meskers">C. 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Coulson</name><affiliation wicri:level="1"><nlm:affiliation>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD</wicri:regionArea><wicri:noRegion>M15GD</wicri:noRegion></affiliation></author><author><name sortKey="Bagley, L" sort="Bagley, L" uniqKey="Bagley L" first="L" last="Bagley">L. Bagley</name><affiliation wicri:level="1"><nlm:affiliation>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD</wicri:regionArea><wicri:noRegion>M15GD</wicri:noRegion></affiliation></author><author><name sortKey="Barnouin, Y" sort="Barnouin, Y" uniqKey="Barnouin Y" first="Y" last="Barnouin">Y. Barnouin</name><affiliation wicri:level="1"><nlm:affiliation>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD</wicri:regionArea><wicri:noRegion>M15GD</wicri:noRegion></affiliation></author><author><name sortKey="Bradburn, S" sort="Bradburn, S" uniqKey="Bradburn S" first="S" last="Bradburn">S. Bradburn</name><affiliation wicri:level="1"><nlm:affiliation>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD</wicri:regionArea><wicri:noRegion>M15GD</wicri:noRegion></affiliation></author><author><name sortKey="Butler Browne, G" sort="Butler Browne, G" uniqKey="Butler Browne G" first="G" last="Butler-Browne">G. Butler-Browne</name><affiliation wicri:level="3"><nlm:affiliation>Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Myologie, GH Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gapeyeva, H" sort="Gapeyeva, H" uniqKey="Gapeyeva H" first="H" last="Gapeyeva">H. Gapeyeva</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Sport Sciences and Physiotherapy, University of Tartu, Tartu, Estonia.</nlm:affiliation><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of Sport Sciences and Physiotherapy, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Hogrel, J Y" sort="Hogrel, J Y" uniqKey="Hogrel J" first="J-Y" last="Hogrel">J-Y Hogrel</name><affiliation wicri:level="3"><nlm:affiliation>Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Myologie, GH Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Maden Wilkinson, T" sort="Maden Wilkinson, T" uniqKey="Maden Wilkinson T" first="T" last="Maden-Wilkinson">T. Maden-Wilkinson</name><affiliation wicri:level="1"><nlm:affiliation>School of Physical Activity and Health, Sheffield Hallam University, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Physical Activity and Health, Sheffield Hallam University, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Maier, A B" sort="Maier, A B" uniqKey="Maier A" first="A B" last="Maier">A B Maier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Human Movement Sciences, MOVE Research Institute, Vrij University, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Movement Sciences, MOVE Research Institute, Vrij University, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Meskers, C" sort="Meskers, C" uniqKey="Meskers C" first="C" last="Meskers">C. Meskers</name><affiliation wicri:level="3"><nlm:affiliation>Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Rehabilitation Medicine, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Murgatroyd, C" sort="Murgatroyd, C" uniqKey="Murgatroyd C" first="C" last="Murgatroyd">C. Murgatroyd</name><affiliation wicri:level="1"><nlm:affiliation>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD</wicri:regionArea><wicri:noRegion>M15GD</wicri:noRegion></affiliation></author><author><name sortKey="Narici, M" sort="Narici, M" uniqKey="Narici M" first="M" last="Narici">M. Narici</name><affiliation wicri:level="4"><nlm:affiliation>Graduate Entry Medicine and Health, University of Nottingham, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Graduate Entry Medicine and Health, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="P Suke, M" sort="P Suke, M" uniqKey="P Suke M" first="M" last="P Suke">M. P Suke</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Sport Sciences and Physiotherapy, University of Tartu, Tartu, Estonia.</nlm:affiliation><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of Sport Sciences and Physiotherapy, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Sassano, L" sort="Sassano, L" uniqKey="Sassano L" first="L" last="Sassano">L. Sassano</name><affiliation wicri:level="1"><nlm:affiliation>Unilever Discover, Colworth Park, Sharnbrook, Bedford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Unilever Discover, Colworth Park, Sharnbrook, Bedford</wicri:regionArea><wicri:noRegion>Bedford</wicri:noRegion></affiliation></author><author><name sortKey="Sipil, S" sort="Sipil, S" uniqKey="Sipil S" first="S" last="Sipil">S. Sipil</name><affiliation wicri:level="4"><nlm:affiliation>Gerontology Research Center, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Gerontology Research Center, Department of Health Sciences, University of Jyväskylä, Jyväskylä</wicri:regionArea><orgName type="university">Université de Jyväskylä</orgName><placeName><settlement type="city">Jyväskylä</settlement><region type="région" nuts="2">Finlande-Centrale</region></placeName></affiliation></author><author><name sortKey="Al Shanti, N" sort="Al Shanti, N" uniqKey="Al Shanti N" first="N" last="Al-Shanti">N. Al-Shanti</name><affiliation wicri:level="1"><nlm:affiliation>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD</wicri:regionArea><wicri:noRegion>M15GD</wicri:noRegion></affiliation></author><author><name sortKey="Stenroth, L" sort="Stenroth, L" uniqKey="Stenroth L" first="L" last="Stenroth">L. Stenroth</name><affiliation wicri:level="4"><nlm:affiliation>Gerontology Research Center, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Gerontology Research Center, Department of Health Sciences, University of Jyväskylä, Jyväskylä</wicri:regionArea><orgName type="university">Université de Jyväskylä</orgName><placeName><settlement type="city">Jyväskylä</settlement><region type="région" nuts="2">Finlande-Centrale</region></placeName></affiliation></author><author><name sortKey="Jones, D A" sort="Jones, D A" uniqKey="Jones D" first="D A" last="Jones">D A Jones</name><affiliation wicri:level="1"><nlm:affiliation>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD</wicri:regionArea><wicri:noRegion>M15GD</wicri:noRegion></affiliation></author><author><name sortKey="Mcphee, J S" sort="Mcphee, J S" uniqKey="Mcphee J" first="J S" last="Mcphee">J S Mcphee</name><affiliation wicri:level="1"><nlm:affiliation>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD, UK. J.s.mcphee@mmu.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD</wicri:regionArea><wicri:noRegion>M15GD</wicri:noRegion></affiliation></author></analytic><series><title level="j">Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</title><idno type="eISSN">1433-2965</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young.</div></front></TEI><affiliations><list><country><li>Estonie</li><li>Finlande</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Finlande-Centrale</li><li>Hollande-Septentrionale</li><li>Nottinghamshire</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Jyväskylä</li><li>Nottingham</li><li>Paris</li></settlement><orgName><li>Université de Jyväskylä</li><li>Université de Nottingham</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Coulson, J" sort="Coulson, J" uniqKey="Coulson J" first="J" last="Coulson">J. Coulson</name></noRegion><name sortKey="Al Shanti, N" sort="Al Shanti, N" uniqKey="Al Shanti N" first="N" last="Al-Shanti">N. Al-Shanti</name><name sortKey="Bagley, L" sort="Bagley, L" uniqKey="Bagley L" first="L" last="Bagley">L. Bagley</name><name sortKey="Barnouin, Y" sort="Barnouin, Y" uniqKey="Barnouin Y" first="Y" last="Barnouin">Y. Barnouin</name><name sortKey="Bradburn, S" sort="Bradburn, S" uniqKey="Bradburn S" first="S" last="Bradburn">S. Bradburn</name><name sortKey="Jones, D A" sort="Jones, D A" uniqKey="Jones D" first="D A" last="Jones">D A Jones</name><name sortKey="Maden Wilkinson, T" sort="Maden Wilkinson, T" uniqKey="Maden Wilkinson T" first="T" last="Maden-Wilkinson">T. Maden-Wilkinson</name><name sortKey="Mcphee, J S" sort="Mcphee, J S" uniqKey="Mcphee J" first="J S" last="Mcphee">J S Mcphee</name><name sortKey="Murgatroyd, C" sort="Murgatroyd, C" uniqKey="Murgatroyd C" first="C" last="Murgatroyd">C. Murgatroyd</name><name sortKey="Narici, M" sort="Narici, M" uniqKey="Narici M" first="M" last="Narici">M. Narici</name><name sortKey="Sassano, L" sort="Sassano, L" uniqKey="Sassano L" first="L" last="Sassano">L. Sassano</name></country><country name="France"><region name="Île-de-France"><name sortKey="Butler Browne, G" sort="Butler Browne, G" uniqKey="Butler Browne G" first="G" last="Butler-Browne">G. Butler-Browne</name></region><name sortKey="Hogrel, J Y" sort="Hogrel, J Y" uniqKey="Hogrel J" first="J-Y" last="Hogrel">J-Y Hogrel</name></country><country name="Estonie"><noRegion><name sortKey="Gapeyeva, H" sort="Gapeyeva, H" uniqKey="Gapeyeva H" first="H" last="Gapeyeva">H. Gapeyeva</name></noRegion><name sortKey="P Suke, M" sort="P Suke, M" uniqKey="P Suke M" first="M" last="P Suke">M. P Suke</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Maier, A B" sort="Maier, A B" uniqKey="Maier A" first="A B" last="Maier">A B Maier</name></region><name sortKey="Meskers, C" sort="Meskers, C" uniqKey="Meskers C" first="C" last="Meskers">C. Meskers</name></country><country name="Finlande"><region name="Finlande-Centrale"><name sortKey="Sipil, S" sort="Sipil, S" uniqKey="Sipil S" first="S" last="Sipil">S. Sipil</name></region><name sortKey="Stenroth, L" sort="Stenroth, L" uniqKey="Stenroth L" first="L" last="Stenroth">L. Stenroth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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